Meeting Banner
Abstract #4525

In Vivo Performance of Myocardial Background Suppression

Terrence Jao1, Hung Phi Do2, Krishna S. Nayak3

1Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; 2Department of Physics, University of Southern California, Los Angeles, CA, United States; 3Electrical Engineering, University of Southern California, Los Angeles, CA, United States

Myocardial arterial spin labeling (ASL) is a technique for measuring myocardial perfusion and perfusion reserve through the subtraction of labeled and non-labeled images. Imperfect subtraction caused by cardiac or respiratory motion will lead to measurement error. In this work, we examine the potential for myocardial background suppression using a saturation-double-inversion-recovery preparation that is compatible with ASL experiments. In six volunteers, myocardial signal was suppressed to 1.14% 1.24% of its equilibrium value.

Keywords

achieved acquisition adiabatic allow alternating arterial award background balanced beats biomedical black blood blue breath broad cardiac caused clinical compatible composed constraints contains dashed designed determined deviation diastole discrepancy dividing double efficiency electrical engineering ensure examine experiment fair fashion feasibility flow foundation free green hard heart holds humans hung hyperbolic illustrated imperfect implementation implemented in vivo individual insensitivity intervals inversion inversions iteratively labeled labeling latter linear longitudinal look magma magnetization makes measured measuring minimized mistiming modification motion myocardial myocardium noise occur optimization oscillation particularly performance perfusion physics physiological place placed potential potentially precession predicted prep preparation proposed providing pulse pulses recovery reduce reduction reports representative required reserve residual respiratory roughly saturation scanning scheme secant selective sensitive shorten shortened simulated simulation slab slice southern spin squared steady subject subtraction subtractive sung supported suppress suppression table tagging tailored target throughput timing timings tissue together trains transient translational volunteer window yellow