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Abstract #4311

Evaluation of a Clinically Feasible Treatment Protocol for MR-HIFU Liver Tumor Ablation in a Porcine Liver Model

Joost W. Wijlemans1, Mario Ries2, Martijn de Greef2, Gerald Schubert3, Max Khler3, Mika Ylihautala3, Lambertus W. Bartels2, Maurice A.A.J. van den Bosch1, Chrit T.W. Moonen2

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Philips Medical Systems MR, Vantaa, Finland

MR-HIFU ablation of highly perfused liver tissue requires high powers with sufficient cool down times. Therefore, ablation of larger volumes will be time consuming and challenging in the clinical setting. In this study, we evaluated a clinically feasible treatment protocol using a porcine liver model. A clinical MR-HIFU system was used to sonicate seven 4mm treatment cells in the liver, which yielded a non-perfused volume of ~2.2ml. Post mortem examination revealed no near field damage. Ablation time was 95 minutes, total treatment time 135 minutes. These results demonstrate that it is clinically feasible to ablate substantial volumes of liver tissue.

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Keywords

abdominal ablate ablated ablation ablations acceptable acoustical addition advancement although anesthesia animal approval assessed beam bursts cause cells challenging chosen clinical clinically collateral committee consequence consuming contrast cool coronal correlated create cycle damage depth diameter diaphragm dose duration duty dynamic edema efficiency enhanced evaluated evidence examination examined except exterior feasible fibrous field flash focus focused frame framework frequency gadolinium gated general grant guided hemorrhaging hepatic highly histological impact induced institute institution intact intensity inter invasive land larger layers least limited limiting limits liver lobe made materials medical medicine metastases middle minutes model molecular muscle navigator near necrosis outcome output path perfused perfusion placed planning porcine position post potentially power preserving project promising protocol proton radiology remained required requires resolution respiratory ribs robustness safety sciences seven short slices soft subsequently sufficient system target therapy thermal thermometry tissue tissues towards translational treatment trial tumor tumors ultrasound unobstructed upcoming valuable variables volume volumes volumetric