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Abstract #4310

MR Guided High Intensity Focused Ultrasound Bone Ablation Assessed with MR, PET, and MDCT Imaging

Matthew Bucknor1, Viola Rieke1, Youngho Seo1, Randall Hawkins1, Mark Wilson1, Sharmila Majumdar1, Thomas M. Link1, Maythem Saeed1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

MR-guided high intensity focused ultrasound (MRgHIFU) is a powerful technique for thermally ablating focal lesions. The purpose of this study was to clearly delineate post-treatment changes in bone following HIFU on MR, PET and MDCT imaging in a swine model. Two discrete ovoid lesions were created at each proximal diaphysis and distal metadiaphysis of the right femur. Follow-up imaging studies at five days demonstrated focal ovoid hypoenhancement and decreased radiotracer uptake (dynamic 18NaF-PET) which correlated precisely to the prescribed targets. CT failed to demonstrate the lesions. This study supports the usage of MRgHIFU in treating focal lesions in bone.

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Keywords

ablated ablating ablation acoustic acquisition adjacent animal animals application applications approval array arrow arrows axial beam begins biomedical bone care cellular characterize clearly committee compartment concordantly consistent constant contrast correlating course created days decreased degree delayed delivered discrete documents done dose duration dynamic edema efficacy enhanced equal expanding failed fast femur five focal focally focused frequent gradient guided guidelines health heating humane impaired institutes institutional integrated intensity interface interstitial intervention inversion invest lateral lava layering layers lesion lesions limb limbs link local margin margins mark metastases modalities model modern muscle national organ ovoid pain painful palliation palliative pathologic perfusion peripheral planning porcine post potential power powerful prior proximal pulse quantitative radiation radiology rapidly received recovery refractory resolution rims samples scanner segmented side sites soft solid specifically spine spoiled structural studies summation swine system systems table target targeted targets temperature therapy thermometry tissue tomography transducer treated treatment ultrasound untreated uptake usage viola