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Abstract #4236

Characterization of Tissue Acidosis Response in Transient Acute Ischemic Stroke with pH-Sensitive APT MRI

Phillip Zhe Sun1, Jerry S. Cheung1, Enfeng Wang1, Xiaoan Zhang2

1Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Radiology, 3rd Affiliated Hospital, Zhengzhou, Henan, China

pH-sensitive APT MRI is a metabolic index that remains promising to define ischemic tissue injury. We evaluated ischemic tissue response to reperfusion with multi-parametric MRI, and our results showed that quantitative pH imaging delineated salvageable DWI lesion from the irreversibly injured ischemic core. Therefore, it is important to develop multi-parametric tissue outcome prediction model that combines perfusion, pH and diffusion MRI, which may more accurately identify salvageable ischemic tissue for late thrombolytic therapy and ultimately help guide the development of neuroprotection agents that target tissue acidosis.

Keywords

acidic acidosis acquisition acute adult affiliated aims amide animal approximately artery asymmetry benign biomedical cascade cerebral characterization china classification coefficient concentration conducted consistent content correlated cubic damage damages decreased deficit deficits delineating developed diffusion displayed displays early effectively endogenous evaluate extrusion fact filament heterogeneous hospital identifies immediately in vivo induced induces injury interestingly interface inversion irreversible jerry labeling lactate lesion lesions likely little localizes male marker matched materials mechanism metabolic middle mismatch model molecular native notably note occlusion often overestimates parametric partially penumbra perfusion positioned post press prior processed promising prompt proton radiology rats reasonably recently recognized recovered recovery refine remains removed representative resolved response reversible salvage salvageable sensitive serves severe side spectra spectroscopy spillover stratify stroke structural substantial suffers suggesting summary surrogate table tissue transfer transient treated treatment upon user variant viable vital weighed whereas widely