Two-Frequency Irradiation of the pH-Dependent Amide Proton Transfer Effect in a Clinical Scanner:simulation and Experiment

Keywords

acidosis adapt additional adjustment algebra although amide amplitude arising assumed asymmetry audience better blue brain built central clinical cognitive cohorts correction cosine cross dashed degradation dependence dependent derived describe described describing detection determined developers dips double duration enable equations error evolution exact example exchange excitation experiment experimental experimentally extensive feasibility frequency furthermore green hours human illustrated immediately improvements in vivo included indicate insufficient irradiated irradiation isolate like limited linear linked linking macromolecules magnetization matrix mobile model modulated novel offset optimizations partial pathological peak phantom phantoms physiologically pool pools posed prepared preset prevent previously prior profile prolonged protein proteins proton protons pulse pulses pure quantification quantitative reading realized reduces relevant reported requires respect respectively reveal reveals samples sampling saturation scanner scheme schemes sciences semisolid setup shape shaped sidebands sigma simulate simulated simulation simulations solid solution solving spectrometer steps strategy studied submitted target tissue tolerate transfer trio truncation tubes utilizing variations varying water whereas white