Meeting Banner
Abstract #4075

Separate Assessment of Fibrosis, Steatosis and Inflammation: Multi-Parametric Imaging of Chronic Liver Diseases

Sabrina Doblas1, Helena S. Leitao1, 2, Philippe Garteiser1, Gaspard d'Assignies1, 3, Feryel Mouri4, Valrie Vilgrain1, 3, Ralph Sinkus1, Carlos F.G.C. Geraldes2, Bernard E. Van Beers1, 3

1U773-CRB3, INSERM, Paris, France; 2Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; 3Radiology Department, Beaujon University Hospital, Clichy, France; 4Hepatology Department, Beaujon University Hospital, Clichy, France

Confounding factors such as steatosis and inflammation can bias the evaluation of hepatic fibrosis by MR elastography or DWI, 2 techniques proposed as non-invasive approaches to the evaluation of chronic liver diseases. Multivariate analysis of MR elastography and DWI data obtained from a cohort of 58 hepatitis patients showed that viscoelastic parameters preferentially responded to fibrosis, whereas the diffusion coefficient was mostly affected by steatosis.

Abstract PDF Presentation Video

Keywords

absence acquisition additional advanced affect affected alternatives applied assess assessment attenuation beers bias biology biopsy cell certainly chronic cirrhotic coefficient coefficients coexist complex confounding consecutively correlated correlation correlations curve decrease determined dictating diffusion discrimination diseases eight either encoding equation establish evaluation even exhibited exponential extensive extracellular fibrosis fifty fitting flank gabs generally grade gradients grading greatly hepatic hepatitis hospital identified included independent inflammation influence influenced intensity invasive inversion linear linked liver local maps matrix mechanical mild model moderate mono mostly motion multivariate negatively normalized offsets often parametric pathological patient patients percutaneous positioned potentially predominantly propagation properties proposed prospective pure radiology rank readout regression resolution resp restricted revealed scheme scoring secondary separate several significantly slightly spin stage stages statistical stiffness strongly subjects tightly tissue transducer underlying underwent univariate usefulness variable viral viscoelastic water wave waves whether