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Abstract #4052

Identification of Brown Adipose Tissue Using Dixon Imaging in a Human Adult with Histological Confirmation.

Sarah C. Wayte1, Narendra L. Reddy2, Terence A. Jones2, Oludolapo Adesanya3, Yen C. Yoe4, Harpal S. Randeva2, Sudhesh Kumar2, Charles E. Hutchinson2, 3, Thomas M. Barber2

1Department of Medical Physics, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, United Kingdom; 2Warwick Medical School, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, United Kingdom; 3Department of Radiology, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, United Kingdom; 4Department of Histopathology, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, United Kingdom

Potentially, Dixon imaging offers a safe reliable method for serial monitoring of brown adipose tissue (BAT) volume. We present the first histologically confirmed identification of BAT in an adult human using Dixon imaging. The patient was imaged using 18FDG PET-CT CT and IDEAL MR. ROIs were identified in areas of high uptake on PET-CT and registered onto the MR images. A significant difference (p<0.0001) was found between the MR signal within these ROIs and neighbouring white adipose tissue (WAT) regions. The overall BAT:WAT signal ratio was (0.890.12). Histology confirmed the presence of BAT in a low signal region identified on MR.

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