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Abstract #4051

in vivo MRI/MRS Characterization of Brown and White Adipose Tissues in Mice: Plasticity Due to High Fat Diet and Pharmacological Treatments

Rossella Canese1, Francesca Cinti2, Andrea Armani2, Vincenzo Marzolla2, Fabio Ginnari Satriani3, Giulia Carpinelli3, Massimiliano Caprio2

1Cell Biology and Neuroscience, Istituto Superiore di Sanit, Rome, Italy; 2Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy; 3Cell Biology and Neuroscience, Istituto Superiore di Sanita', Rome, Italy

Brown adipose tissue (BAT) is currently a topic of interest in obesity and metabolic research due to its physiological relevance in human adults and can be detected by MRS. Aim of the study was to monitor metabolic and volumetric changes in adipose tissue as a result of high fat diet and after pharmacological treatment with mineralocorticoid receptor antagonists, namely drospirenone (DRSP) and spironolactone (Spiro), in subcutaneous (inguinal) and visceral (perivescical) areas. Both the treatments detected an increase in the water/fat (as lipid signal at 0.9 ppm) ratio in the inguinal fat depots and a reduction of perivescical fat volume.

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Keywords

abdomen absence accordance active actively activity adipose administered adults alterations alto among analyses analyzed animals antagonism antagonists applied assessed assessment axial biology biomedical blockade body brown browning cardiovascular cell characterization characterized close coil collected composition concomitant coronal countered currently cytoplasm decoupled deposit depot depots detect determination diet differential droplet droplets drugs either employed endocrinology endowed evaluate evidence evidenced examined expressed extremely female fisher fitting gland histological human in vivo induced inguinal interspersed intracellular inversion laboratory like lipid longer macroscopic maintenance mammary marked markedly matrix measured metabolic mice microscopic models monitor mono moreover morphological namely obesity operating pellets percentage period pharmacological physiological plasticity positioned progressively pulse quality quantification quantitative rapid receiver receptor recovery reduced related releasing relevance report reported respect respectively rich richer rodent several significantly slices software spectra spectral steam structure subcutaneous suggesting surface system thank tissue tissues topic towards transients transmitter treated treatment treatments trend vehicle visceral volume volumes water weeks white