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Abstract #4047

Effect of Withania Somnifera on Seminal Plasma Metabolites of Infertile Males: A Proton NMR Study

Ashish Gupta1, Abbas Ali Mahdi2, Mohammad K. Ahmad2, Navneeta Bansal2, Pushplata Sankhwar3, Satya Narain Sankhwar4

1Centre of Biomedical Magnetic Resonance, SGPGIMS Campus, Lucknow, UP, India; 2Department of Biochemistry, King Georges Medical University, Lucknow, UP, India; 3Department of Obstetrics & Gynecology, King Georges Medical University, Lucknow, UP, India; 4Department of Urology, King Georges Medical University, Lucknow, UP, India

Efficacy of Withania sonmifera (W. somnifera) were evaluated on metabolic profile of seminal plasma of infertile patients (n=180). Patients were administered (5g/day) W. somnifera root powder for three months. Lactate, alanine, choline, citrate, glycerophosphocholine (GPC), glutamine, tyrosine, histidine, phenylalanine, and uridine were measured in seminal plasma using 1H NMR spectroscopy. W. somnifera therapy repairs the disturbed concentration of lactate, alanine, citrate, GPC, histidine and phenylalanine in seminal plasma and recovers the quality of semen of post-treated infertile men with compared to pre-treated. Results suggest that W. somnifera may be used as an empirical therapy for infertility treatment and clinical management.

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Keywords

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