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Abstract #4046

Single Voxel MEGA-Edited GABA and Short TE 1H MRS in Hippocampus and Other Brain Regions Implicated in Bruxism

Shalmali Dharmadhikari1, 2, Ulrike Dydak1, 2, Mario Dzemidzic2, 3, Laura Romito4, Kenneth Byrd4, 5

1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States; 3Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States; 4Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, IN, United States; 5Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States

To establish the feasibility of in vivo GABA and other metabolite quantification in the brain regions implicated in bruxism, short TE and MEGA-edited GABA 1H MRS measurements were performed in bruxer and control subjects at 3 T. In vivo GABA measurement was successfully achieved in the hippocampus and group differences in major metabolites were detected in the hippocampus and thalamus.

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Keywords

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