Meeting Banner
Abstract #3991

in-vivo Detection of GABA Using Short-TE MRS at 3 Tesla

Jamie Near1, Phil Cowen2, Peter Jezzard3

1Centre d'Imagerie Crbrale, Douglas Institute, McGill University, Montreal, Quebec, Canada; 2Department of Psychiatry, University of Oxford, Oxford, OXON, United Kingdom; 3FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom

In this study, we investigate the reproducibility of short-TE MRS measurements of GABA in the human brain at 3 Tesla. These investigations are performed through a) comparison of short-TE GABA measurements with gold-standard edited GABA measurements in the same voxel in-vivo, and b) assessment of within-session reproducibility of short-TE GABA measurements. Across 14 subjects, a significant positive relationship was observed between short-TE and edited GABA measurements (R=0.58, p<0.05), and the average coefficient of variation of multiple within-session short-TE GABA measurements was 8.7 4.9%. These results suggest that short-TE MRS may provide a reliable option for quantitative detection of GABA at 3T.

Abstract PDF Presentation Video

Keywords

according acid acquisition advantageous alternative analyzed analyzing applied array assess assessed automated averaging axis basis blocks body brain breaking chain coefficient coil combination commonly concentration concentrations conditions consecutive consent consisted containing corrections corrupted cortex datasets described detect detection drift edited editing employing enables equal experimental experimentally female field fitting frequency gamma gold head human identically illustrated illustration in vivo individual informed inhibitory institute involved kingdom localized male mammalian measures measuring mega metabolite metabolites motion near neurotransmitter oxford peak peter plot plotted positive post press previously primary prior processed processing psychiatry published reasonable receive recently relationship reliability reliable removal repeated representing reproducibility scanned scanner semi separately session short simulated simulations simultaneous simultaneously special spectra spectral spectroscopic spectrum splitting strength subject subjects suggests transmitter trio typical variation visual volunteers width written