Statistical Strategy to Overcome Estimation Bias in CRLB Threshold Approach for LCModel Analysis of MRS

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accessed activity added addition additionally affected alter alternative although analyses applied approaches arithmetic basis beneficial bias black bound brain brains broadening brooks capability characterization choosing city closer collected concentration concentrations containing contrast cortex cram crucial curves dashed defined derived described desired detecting determined deviations diagnosis dimension disease disturbance disturbed domain early empirical error essential estimation evaluate even example exclude exhibit exhibited exhibits experimental experimentally expressing fields fitting fittings frequency generated graph graphs impact implement implementing in vivo included inconclusive increment indicate induced injection inputs integrative intense investigation localized measures medical metabolite metabolites molecular much neurology noise none noninvasive notable observations obvious outcome outcomes overcome panel particularly passing peaks physiology ping precisely previous prior procedure profiles progression random rats reliability represent representing respectively resultant selected selection several similarly simulated simulation smaller spectra spectral spectrum stability stages statistical statistics still stimulated strategy subject subtle summary threshold thresholds trace tung type uncertainties upon valid varying young