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Abstract #3980

Mapping of Brain Metabolite Distribution by Short Echo Time Echo Planar Spectroscopy Imaging (EPSI)

Angle Lecocq1, Yann Le Fur1, Andrew A. Maudsley2, Sulaiman Sheriff2, Mohammad Sabati2, Virginie Callot3, Monique Bernard4, Maxime Guye1, Jean-Philippe Ranjeva1

1CRMBM, CNRS, Aix-Marseille Univ, MARSEILLE, France; 2Department of radiology, Miller School of Medicine, University of Miami, MIAMI, FL, United States; 3Aix-Marseille University, MARSEILLE, France; 4Aix-Marseille Universit, MARSEILLE, France

Detection of abnormal global quantification of metabolites in case of diffusive pathologies, or abnormal metabolites spatial distribution for local pathologies, required the knowledge of variations in metabolites relative concentration across whole healthy brains. Nevertheless, there is a lack of metabolite quantitative information using a short echo time technique. In this study, we aimed to provide normative values of three major metabolites (Choline, N-Acetyl-Aspartate and Creatine) using a recent whole brain MRSI sequence called Echo Planar Spectroscopy Imaging (EPSI) with short echo time (20ms).

Keywords

abnormalities abstract accounting accurate addition adults allowing analyses anterior appeared applied applying arbitrary artifact artifacts audience brain cerebral channel choline clinical cohort coil community compatible computed conducted consent corrections covered defined density derived deviation deviations diffuse distribution distributions drop evaluated evidence excitation extracted focal gave global glutamate gradient gray head healthy help heterogeneous improve included informed institutional inter interleaved jean larger largest limit locate magnetization major mapping maps masks matrix medicine metabolic metabolite metabolites midas might miller minimize neurological nevertheless normalized normative onto orientation others outside package participating pathologies people pixels planar population posterior power preliminary prepared procedures processing protocol psychiatric radiology ranging rapid realized really receiver regional remove respect robust robustness scale school segmentation selected sheriff short slices software spatial spectroscopy statistical step subject subjects susceptibility system table target template templates threshold thresholded tilted toolbox unit units univ upper variance variations various volunteers water white whole wise women written young