Meeting Banner
Abstract #3918

Evaluation of Renal Metabolic Response to Partial Ureteral Obstruction with Hyperpolarized 13C MRI

David J. Niles1, Jeremy W. Gordon2, Gengwen Huang3, Kevin M. Johnson1, Arjang Djamali4, Sean B. Fain1, 5

1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 3Surgery, University of Wisconsin, Madison, WI, United States; 4Medicine, University of Wisconsin, Madison, WI, United States; 5Radiology, University of Wisconsin, Madison, WI, United States

Congenital obstructive nephropathy is the most common cause of end-stage renal disease in children, and there is a need to improve tools for early diagnosis. In this study we used hyperpolarized 13C MRI to longitudinally and non-invasively assess the hemodynamic and metabolic changes in the kidney following partial unilateral ureteral obstruction. We observed reduced blood flow to the obstructed kidney and a preferential shift toward glycolysis in both kidneys. Our results may contribute to the understanding of the pathogenesis of obstructive nephropathy and to the development of improved approaches for clinical assessment.

Abstract PDF Presentation Video

Keywords

acknowledge acknowledgments alto anatomic anesthesia animals applications approaches arrow assess audience beginning blood bottom cause caused children clinical clinicians closely common complete complied congenital contribute curve days delivery demand derived development diagnosis diagnostic died disease disorders echoes estimation fain fasting female five flow gratefully greater hill horizontal hours human improved indicates injected injection investigate investigation iterative just kidney kidneys lactate least longitudinal longitudinally major markedly matrix median medical medicine metabolic metabolism metabolite mice model models monitoring mouse needed negative obstructed obstruction obstructive overlaid oxidative oxygen partial pathogenesis perfusion physicists physics pilot placed plots policies post potential precluded prior production pronounced qualitative quantitatively radiology rather recent reconstructed reduced reduction related remained remaining renal resemble resolution response sample scale several shot slice slightly spiral squares stage statistical steady suggest suggesting support surgery surgically system tail target temporal together toward transplant trend trends understanding unilateral unobstructed ureter vein volume warranted weeks white whole windowed