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Abstract #3917

Optimized Sampling of Metabolically Labeled [2-13C]Lactate Following Injection of Hyperpolarized [2-13C]Pyruvate

Ralph Hurd1, Sonal Josan2, 3, Jae Mo Park2, 4, Yi Fen Yen2, Dirk Mayer2, 3, Daniel Spielman2, 4

1GE Healthcare, Menlo Park, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Neuroscience Program, SRI International, Menlo Park, CA, United States; 4Electrical Engineering, Stanford University, Stanford, CA, United States

With the increased use of hyperpolarized [2-13C]pyruvate in metabolic spectroscopy and imaging, there is an emerging need for optimized sampling of the metabolically labeled [2-13C]lactate. Toward that goal, the T1 of [1-13C]lactate was measured in vivo and used to calculate optimum flip angles for time-resolved spectroscopic data collection. An equimolar mixture of 40 mM [1-13C]pyruvate and 40 mM [2-13C]pyruvate was used to compare the apparent in vivo T1s and to optimize the time-resolved sampling of [2-13C]lactate with [1-13C]lactate.

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Keywords

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