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Abstract #3906

Effect of Moderate Hyperthermia on Inflammation Following Experimental Traumatic Brain Injury in Mice

Lesley M. Foley1, Steven L. Shein2, 3, Vincent A. Vagni2, T Kevin Hitchens4, 5, Chien Ho4, 5, Patrick M. Kochanek2, 6

1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh , PA, United States; 2Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 3Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 4Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States; 5Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States; 6Departments of Critical Care Medicine, Pediatrics and Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States

Secondary insults are known to worsen outcome following traumatic brain injury (TBI). Though there is conflicting clinical evidence with regards to hyperthermia, it is generally considered as detrimental and for patients that exhibit pyrexia it is important temperature control. In animal models there is no question about the role of hyperthermia and its detrimental effect on outcome. In our study there was a significant increase in macrophage influx to the brain following TBI and moderate hyperthermia.

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Keywords

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