Meeting Banner
Abstract #3688

MR Spectroscopy of Hypobaric Hypoxia Induced Changes in Rat Brain Hippocampus Using 7Tesla

Sunil Koundal1, Sonia Gandhi1, Tanzeer Kaur2, Subash Khushu1, Rajendra P. Tripathi1

1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi, India; 2Department of Biophysics, Panjab University, Chandigarh, Panjab, India

High altitude related exposure results in decreased oxygen supply to brain. Brain being most sensitive to hypobaric hypoxia, gets adversely affected. Our study investigates the changes in metabolic profiles of rat brains hippocampus region due to acute hypobaric hypoxia stress and recovery using invivo magnetic resonance spectroscopy. Results showed significant decrease in levels of glutamate,myoinositol,NAA,creatine but increase in choline indicating hypobaric hypoxia induced damage in hippocampus of rat brain. These studies can be helpful in detecting early biomarkers for high altitude stress injuries in humans which can further be used for risk assessment & early diagnosis.

Keywords

acute adversely affected affects allied alterations altered altitude analytical analyzed appears army assessment automatic availability back biochemical biophysics brain carried cellular chamber choline climatic conditions consequence constant control controls coronal correlated damage days decrease decreases defect degeneration deleterious detect detection diagnosis early energy exposed exposure expressed external feet free glutamate health help human humans humidity hypoxia identifying immediate in vivo indicates induced institute institutional interplay intracellular irreversible known located loss lungs male marker materials measures medicine membrane messenger metabolic metabolism metabolite metabolites might miller model molecular mountain natl neuronal neurons nuclear objective occurring organs oxidative oxygen pairwise particular particularly pathways placed plotted post potential powerful precursor predominantly pressure presumed pretreated probably processed proton psychiatry quantification radical rats recover recovery regulated respectively response reveals risk room sciences sensitive sickness slice spectra spectroscopy stimuli stress subtle system systemic temperature temporal tool trekkers troops turn turnover undergoes understand understanding units utmost various vital vitro vulnerable weeks