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Abstract #3686

Resting State Network in ADHD Rat Model Using Group ICA

Yi-Ling Wu1, Sheng-Min Huang1, Shin-Lei Peng1, Yi-Chun Wu2, Tao-Chieh Yang3, Jee-Ching Hsu4, Ming-Long Wu5, Fu-Nien Wang1

1Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Animal Molecular Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3Department of Neurosurgy, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan

In this study we investigated the resting state (RS) networks of attention deficit and hyperactive disorder (ADHD) using spontaneously hypertensive rats (SHR). RS network of SHR was found to be more active than normal rat in primary somatosensory (S1) and insular cortex region. The hyperactivity in S1 is speculated to be the possible reason of attention deficit since rats are sensitive to external changes. Though the detail connections of RS network and physiological functions should be further examined, our works suggest the feasibility to evaluate RS network differences by rat model. More case studies of ADHD could be conducted via rat model.

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Keywords

abnormality according activation activations animal attention automated behavior bilateral biomedical body brain carefully carried chromosome circulation coil column commonly comparing component computer conducted connections consequently contrarily coordinates cortex deficit discover discovered disorder disorders drugs emotion engineering environmental evaluate examined examining exhibited exist experiment expression external failure feasibility field filtering frequency function functional future genetic gift gradient heart hospital human hyperactive hypertensive implies impulsive inconsistent induced influences inhibitory insular intensities intensity interestingly investigations irregular listed locations long maintained male maps material matrix memorial ming mixed model models molecular monitored moreover national natl need network networks neural note numerous package particular period possibility primary process processed proved rats reason receiving registration related reports represents respectively respiratory rest resting scanned science sciences score secondary sensitive shin since slice slices smoothing software somehow speculated spontaneously stronger studied studies suggesting surface syndrome table temperature temporal throughout timing toolkit tools underscoring validation various water weaker whole yang