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Abstract #3236

Deep Brain Stimulation at the Subthalamic Nucleus Produces fMRI Response in the Motor Cortex

Hsin-Yi Lai1, John Robert Younce1, Yu-Chieh Jill Kao1, Hong Yuan2, Yen-Yu Ian Shih1

1Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, United States; 2Department of Radiology, University of North Carolina, Chapel Hill, NC, United States

This study demonstrates unexpected BOLD fMRI response in the motor cortex as a result of DBS at the STN. This response is frequency dependent, peaking at 100 Hz with increased glucose metabolism as confirmed by FDG-microPET. This pattern of frequency-dependence suggests a relationship to the therapeutic effect of STN DBS for Parkinsons disease which may be further investigated by the use of this technique in parkinsonian animal models.

Keywords

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