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Abstract #3234

Direct Non-Invasive MRI Measurement of the Absolute CBV-CBF Relationship During Sensory-Motor and Auditory Stimulation in Normal Humans

Pelin Aksit Ciris1, Maolin Qiu1, Robert Todd Constable1

1Diagnostic Radiology, Yale University, New Haven, CT, United States

BOLD signal reflects changes in CBV, CBF, blood oxygenation and metabolism, the quantification and physiological interpretation of which typically assumes that CBV=0.88CBF0.38 based on PET monkey measurements by Grubb et al. In this study, the absolute CBV-CBF relationship was measured directly in MRI non-invasively on 15 volunteers during sensory-motor and auditory stimulation. Measurements were within physiologically expected ranges, consistent with prior publications. Non-invasive characterization of the CBV-CBF relationship in humans under various metabolic or functional challenges can advance understanding of fMRI signal mechanisms, with further potential clinical utility in vascular state or treatment monitoring.

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Keywords

absolute acquisition acquisitions activation adiabatic agreement allowing apposition approved arterial assume auditory averaging bilateral bilaterally binaurally biophysical blocks blood bold bolus brain brains calibrated calibration challenges clinical consecutively considered consisted consistent consistently contribution contributions control corrected cortical covering cycles defined deviations diagnostic difficult direct disease durations especially evaluating except excluded expected exponent exponents expression extension fair fifteen finger fits fitting form function functional good gradient great haven human humans hypo improved induced interpretation invasive inverse inversion knowledge labeled linear masks mechanisms median metabolism modalities model monitoring motion motor noise noninvasive observations original overlap oxygenation partial physiological potential power practice previously processed providing published quantified radiology random recovery reflect reflects regional relationship reported respectively resting sensory separated served since slice smaller sounds space species steady stimulation stimuli stimulus stroke subjects superior tapping thirteen throughout thumb tracking transverse treatments typically understanding upon utility validation vary varying venous versus verve vessels volunteer volunteers whole