Meeting Banner
Abstract #3083

On the Application of Anomalous Diffusion Metrics in Animal Stroke Models

Farida Grinberg1, Ezequiel Farrher1, Luisa Ciobanu2, Nadim Jon Shah1, 3

1Institute of Neuroscience and Medicine 4 - Medical Imaging Physics, Forschungszentrum Juelich, Juelich, Germany; 2Neurospin, CEA, Gif-sur-Yvette, France; 3Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

We analyse the sensitivity of the stretched- exponential model in providing contrast for ischemic lesions in animal stroke models. Good fits in the extended range of the diffusion weightings were obtained. In frame of the proposed analytical models, the stretched-exponential function is indicative of anomalous diffusion mechanisms and provide complementary means to infer valuable microstructural information. We obtained promising results in terms of image contrast and better understanding of pathological changes in the ischemic lesions.

Abstract PDF Presentation Video

Keywords

abstract accompanying advanced among animal animals anisotropy anomalous applicability application applications approaches assessment attenuations audience beading better brain called cascade cell cellular cerebral clear clinicians coefficient complementary considered contrast contrasts cortex dealing decrease described details deviations diffuse diffusion diffusivity disorder distributed distribution elsewhere enhanced enhancement enlargements evaluated evaluates even exceeding exhibit exponent exponential faculty findings fits focal fractal fractional frame free function gained gold hall healthy heterogeneity histograms hours humans increasing index indicate infer institute investigate investigation kurtosis larger largest latter lesions located magnitude maps materials medical medicine metrics model models molecules mono much neurology particular pathological pathologies physics previous processes projections promising properties proposed providing quantitative recent regarding related reported researchers respect satisfactory selected sensitivity several shah slices smallest stretched stretching striking stroke stronger structural substantiated swelling target terms tissue understanding valuable years