Meeting Banner
Abstract #2432

MR Elastography as a Method to Determine the Mechanical Properties of Fresh and Formalin Fixed Porcine Hearts

Ria Mazumder1, Bradley Dean Clymer1, Richard White2, 3, Arunark Kolipaka2, 3

1Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States; 2Deparment of Radiology, The Ohio State University, Columbus, OH, United States; 3Deptarment of Internal Medicine, Division of Cardiology, The Ohio State University, Columbus, OH, United States

Formalin fixed hearts have been actively used in research to study mechanical properties such as stiffness of left ventricular (LV) myocardium. However, the stiffness of the fresh hearts greatly differs from that of the formalin fixed hearts. Mechanical testing has been the gold standard to determine the stiffness of the myocardium. In this study MR Elastography is used to compare the stiffness of LV myocardium between fresh and formalin fixed hearts within the same animal specimen. We have observed that formalin fixed hearts are significantly stiffer than the fresh hearts.

Abstract PDF

Keywords

alters animals applied applying audience axis balloon band biomedical built cardiac cardiology changing clinic column columns computer covering custom days dean determine direct directional displaying dissected division done driver duration electrical encode encoding engineering engineers entire estimation filter fixation fixed formalin frequency fresh furthermore gradient gradients graph heart hearts hours in vivo included inflate inflation inserted integral internal introduced invasive inversion isotropic longitudinal magnitude maps masked matrix mayo mechanical medical medicine motion muscle muscles myocardial myocardium novel offsets others part pass pigs pneumatic porcine post pressure processed properties quantitative radiology rapid reflected remove reported representing represents resolution scanned scanner scanning short significantly slice slices soft software spatial stiffer stiffness stored strips student system targeted tissues trio variation variations ventricular vibration views wave waves white