AIF Induced Limits of Parameter Uncertainty in Pharmakokinetic Models of Pre-Clinical DCE-MRI

Keywords

accuracy achievable achieved actual added administered administration admission advanced agent amount animal applicable appropriate arterial astronomy audience biomedical blood bootstrapping challenging choice chosen clinical college colors concentration consists constant contrast control conveniently convolution corresponds crucial curve curves defined density derived described desired determination determine determining deviation difficulty distribution dose duration dynamic enhanced evolution examined expected explores extracellular feasible final fits fitting form formalism fulfill function functional fundamentally grows heart histograms ignored impulse induced injection input intrinsically investigator keeping knowledge known largely leach lies limit limitation limits magnitude maintaining major measured methodology model modeling models monotonically moreover mouse much narrow noise offset ones particularly peak phys physics physiological physiologically plasma population predict previously procedure projection protocol protocols quantify question reason represents reproducibility requirements resolution response scaled slower space speed steps subsequent system tail target temporal throughout tissue trans transfer tumor typical typically uncertainty various vertical virtually walker wide width yield yields young