Meeting Banner
Abstract #2055

Full Optimization of Multi-Shell Diffusion Acquisition Schemes for Advanced Microstructural Imaging

Silvia De Santis1, Yaniv Assaf2, Derek K. Jones1

1CUBRIC Cardiff University, Cardiff, United Kingdom; 2Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel

A comprehensive optimisation of the experimental acquisition scheme for advanced microstructural imaging is developed, optimising and comparing different approaches reported in the literature though both Monte-Carlo simulations and in vivo acquisitions. As a result, an optimised protocol for multi-shells acquisitions is proposed, that balances scan duration with accuracy/precision on the estimated parameters, needing only a 12 minutes acquisition for whole-brain maps of the axonal density and the fibre orientation.

Keywords

according accuracy acquisition acquisitions addressed advanced allows angular anisotropy apart approaches arrangement assessed assumption balance balances ball best better brain characterize charmed closer collected collecting comparing compartment compartments comprehensive context contributions coverage crossing datasets date density developed diffusion duration dynamics error even exactly example experimental experimenters expressing fewer finding full giving gradient healthy highest hindered hybrid identified identify illustration implicit in vivo inadequacy increasing issue kingdom lack largest leveraged literature longer mainly maintains maps matrix maximized minutes model models need needing neurobiology noise onto optimal optimally optimization optimized orientation orientations others outperforms partially particularly population precision press produce projected proposed protocol providing pulses ranging real removing repeating reported reproducibility resolution respect respectively restricted scheme schemes search separation sessions setup several share shell shells short shortest simulated simulations smaller specificity spin stick striking subject summation synthetic system target teasing temporally tensor though tissue truncate uneven unique upper useful volume walkers white whole wishing years