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Abstract #1973

Effects of Cafeteria Diet and Voluntary Running on Brain Structure and Metabolism in Mice

Markus Sack1, 2, Johannes Fuss3, Claudia Falfn-Melgoza2, Sarah Biedermann, 12, Matthias Auer4, Jenny Lenz4, Gabriele Ende1, Alexander Sartorius, 25, Peter Gass3, Wolfgang Weber-Fahr, 12

1Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany; 2RG Translational Imaging, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany; 3RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany; 4Endocrinology, Max Planck Institute of Psychiatry, Munich, Germany; 5Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany

Obesity is one of the major health burdens of modern societies associated with a great variety of health-threatening sequela such as diabetes, cardiovascular diseases, cancer and even psychiatric disorders. We conducted a MR spectroscopy study investigating metabolic changes in a cafeteria-mouse model vs. control mice receiving standard chow in the right hippocampus and prefrontal cortex area in conjunction with VBM analyses. We found that physical exercise and cafeteria diet have opposite effects. While exercising mice show increased metabolite concentrations (NAA+NAAG and Glu+Gln) and increased volume within the hippocampal area, cafeteria diet counterparts the metabolic effect without impact on brain structure.

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Keywords

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