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Abstract #1927

PHIP-Enhanced Natural Abundance 13C Imaging in a Clinical MRI System Via 1H/13C Polarization Transfer

Dirk Graafen1, 2, Jan Falk Dechent1, 2, Michael Ryan Hansen2, Kerstin Mnnemann2, Hans Wolfgang Spiess2, Laura Maria Schreiber1

1Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Max Planck Institute for Polymer Research, Mainz, Germany

Aim of this study was to realize transfer of 1H hyperpolarization to 13C in a clinical MRI system utilizing parahydrogen induced polarization (PHIP). The transfer was achieved by a modified refocused INEPT sequence (PH-INEPT+) which was sequentially transmitted since most clinical MRI systems are only equipped with a single RF transmitter channel. The generated hyperpolarized 13C state for natural abundance hydroxyethylpropionate was used for MRI employing the RARE sequence with 64 images acquired in the echo train. A single acquisition of an image yielded an SNR of 13 that could be increased to 40 by averaging in the echo train.

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Keywords

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