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Abstract #1882

A Novel Targeted MRI Contrast for Glioma Using Interleukin-13 Receptor Conjugated Liposome

Xiaoli Liu1, A.B. Madhankumar1, Patti A. Miller2, Becky Webb1, Kari A. Duck1, James R. Connor1, Qing X. Yang, 12

1Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, United States; 2Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, PA, United States

Previous work demonstrated that inteleukin-13 receptors alpha 2 (IL-13R&[alpha]2) are highly expressed in glioma cells, but not in the normal cells. Thus, the IL-13R&[alpha]2 receptor was used as a target for delivering MRI contrast agent specifically to gliomas. In this work, we demonstrated that our targeted liposomes captured infiltrating tumor that were totally absent in Magnevist-enhanced MRI.

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