Meeting Banner
Abstract #1881

Water-Soluble Gadolinium Nanoparticles Coated with DO3A-Benzothiazole Conjugate: Synthesis and Application as a Potential Theragnostic Agent

Min-Kyoung Kang1, Hee-Kyung Kim1, Ki-Hye Jung2, Ji-Ae Park3, Seung-Tae Woo4, Joo-Hyun Kim4, Eun-Young Jeon5, Tae-Jeong Kim2, Yongmin Chang1, 6

1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea; 2Applied Chemistry, Kyungpook National University, Daegu, Korea; 3Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science, Seoul, Korea; 4Bayer Healthcare, Medical care, Seoul, Korea; 5The Advanced Medical Technology Cluster for Diagnosis & Prediction, Kyungpook National University, Daegu, Korea; 6Diagnostic Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea

Gadolinium nanoparticles (GdNPs) based perfectly soluble potential theragnostic agents formulated as Gd@SiO2-NHCO-DO3A-BT. The preparation initially requires the formation of Gd@SiO2 through self-condensation of TEOS on the surface of GdNPs. Gd@SiO2-NH2 thus formed was dispersed in diethylen glycol to react with APTES. In order to increase solubility as well as used by potential bimodal contrast agents, Gd@SiO2-NH2 was further conjugated with DO3A-benzothiazole to give the desired product Gd@SiO2-NHCO-DO3A-BT. Gd@SiO2-NHCO-DO3A reveals high MR relaxivity (R1 = 8.29 mM-1s-1) and may be put into a new family of potential multifunctional MRI/optical CAs.

Abstract PDF

Keywords

ability according acquisition activity advanced agent agents amount analytical anesthetized animal anti application become bimodal biological bladder body breast brightest cancer care carried cell cells characterization chemistry chemotherapy cluster coated coil commercial complete completely complexes concentration conjugate conjunction contrast contrasting coronal detail diagnosis diagnostic distinguish engineering enhanced enhancement example exhibit expectation expected family field form formation functions gadolinium homemade in vivo include indeed injection inner institute intensity inversion investigate ions kidney known least linear literature liver made make male maps material materials matrix measured medical medicine mice modified molecular namely national neutron observation optical ovarian oxygen paramagnetic park pattern powerful prediction prominent properties radiological radiology rather reagents received receiver recent recovery renal repetition replaced resolution respectively risen route scheme science select series serve soft solubility soluble sources spatial spectroscopic spin square squares studies supports synthesis system systems table tail targeting therapeutic therapy toward tumor type unit variable various view water whole years young