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Abstract #1875

Development of Targeted Paramagnetic Nanoparticle for Non-Invasive Tumor Imaging

Meser M. Ali1, Nadimpalli RS Verma1, Janic Branislava1, James R. Ewing2, Robert A. Knight2, Ali S. Arbab1

1Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Neurology, Henry Ford Hospital, Detroit, MI, United States

Water soluble membrane peptide (pHLIP) is conjugated with anionic dendrimer-based paramagnetic nanoparticle. pHLIP-tagged nanoparticles bind to and are internalized by breast cancer cells in vitro. Systemic delivery of dendrimer-based nanoparticles lead to accumulation of the nanoparticles in a flank mouse model of breast cancer that are detected by optical and MR imaging.

Keywords

ability accumulation achieve acidic acidosis administration agent aggressive analyze anionic approximately architecture assay attached basis bind biotin bluer breast cancer cells cellular chem chemical circulating clearly clinical clinically concentration conjugate conjugated considerable contrast coupled cross degree delivery dependent depict detected development drainage drug drugs effective efficacious electron england equation exhibit exploited extent extracellular final finally flank fluid fluorescence folding ford generated graphical great hallmark hence henry hospital hours human impaired incubated ineffective injection insertion instruments internalized interstitial intracellular knight limitations linker locker long look malignant maps materials matrix media membranes microscopy minute minutes model mole molecules mouse neurology nuclei optical panel paramagnetic parametric particle passive payload peptide peptides pixel post principle prior produce progress promise purified radiology reacted relatively responsive revealed reversibly review roughly science scientific serially side significantly since solid structural surface target targeted targeting terminus thick toward transmission treatment true tumor tumors typically unique unreacted uptake viable visualized vitro