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Abstract #1837

Magnetic Resonance Elastography for Measuring the Compliance of Occlusive Vascular Disease

Brian S. Kates1, Kevan J. T. Anderson1, Graham A. Wright1

1Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

Percutaneous arterial revascularization of chronic total occlusions (CTOs) is hindered by the presence of a hard proximal fibrous cap and lack of image guidance. A technique is presented for measuring the stiffness of occlusive lesions that may facilitate revascularization by helping the process of guidewire selection and placement. In this study, static magnetic resonance elastography is explored as a method of determining the stiffness of CTOs. The technique is demonstrated in a CTO phantom made of agar and gelatin, and displacement images are obtained using a stimulated echo MR imaging pulse sequence and a pneumatic compression system.

Keywords

absorption according acquisition activated agar agreement allowed although analytical apparatus applied around arterial arteries artery audience axis challenging characterize come complex compliance compressed compression consisted constant contrast controlled core cross curve cyclic cylinder deformation delivered derived determined differential difficult dimensional disease displacement drop either electronically eliminate equation equations expansion explores extent fibrous fitting focus force function functions future good gradual guide hard helpful hyperbolic included indicated indicates inhomogeneity interactions interface interventions inverse known length lesion loading mapping measure measured measuring mechanics mimic mixing mixture modality modulus necessary novel occluded occlusion occlusions occlusive overall penetrate percutaneous phantom plastic plot pneumatic predict prominent pulse pulses quasi readout relatively remained represents resistive response samples scanner section selection separate separated sharp shear simulated simulation since slope soft solution static stiffness strain subjected sudden surface surrounding system taken target theory third tissue tissues towards trans transients transition transitioning type usually valuable valve verified vessel visible young