Meeting Banner
Abstract #1720

Towards MRI Differentiation of Recurring Tumor from Delayed Radiation Necrosis

Carlos J. Perez-Torres1, John A. Engelbach1, Jeremy Cates2, Dinesh K. Thotala2, Robert E. Drzymala2, Joseph J.H. Ackerman3, 4, Joel R. Garbow1

1Department of Radiology, Washington University in Saint Louis, Saint Louis, MO, United States; 2Department of Radiation Oncology, Washington University in Saint Louis, Saint Louis, MO, United States; 3Department of Radiology, Washington University in St. Louis, Saint Louis, MO, United States; 4Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO, United States

Standard anatomical MRI is incapable of differentiating recurring tumor from delayed radiation necrosis, as both lesions are hyperintense. The work presented here investigates mouse models of radiation necrosis and brain tumor with more advanced MRI methodologies, including diffusion-weighted imaging (DWI) and magnetization transfer contrast (MTC). Both tumor and necrosis showed decreases in MTR, with the MTC effect being stronger for tumor than radiation necrosis. The ADCi for tumor was similar to that of healthy brain, while ADCi was elevated in necrosis. A multi-contrast approach that includes both modalities might lead to a framework for differentiating between these pathologies.

Abstract PDF Poster PDF

Keywords

able accurate accurately actively advanced anatomical anesthetized animal anterior apparent applied approved assessment audience bottom brain cancer cells characterization clinicians coil column comparative contrast cortex cortical datasets days decisions decoupled decreases delayed develop developed deviation diagnose diagnosis differentiate differentiating differentiation diffuse diffusion distinguishing dose drawn earlier elevated encoding essential examined explored female field frame frequency goal head healthy histological holds hope humans identify incapable includes injected injection investigates irradiated irradiation isotropic john knife lesions likely localized longitudinally lost magnetization medicine methodologies metrics mice minutes modalities model models mouse necessary necrosis necrotic normalized novel paradigm pathologies patients phys post posterior power predominantly previous previously primary prior produce progression project promise proper pulse radiation radiology recapitulates receive recurrence recurring reported restrained robust saint saturation scanner secured separate several side since site slices stronger student studied studies surface surrounding target third towards transfer transmit treatment tumor tumors ultimate unilateral unlike validated variable volume weeks