DCE-MRI Evaluation of Eribulin Mesylate in MX-1 Triple Negative Human Breast Cancer Mouse Xenograft Model

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abstract according acquisition activity acute addition advantage analog anatomic anesthetized approved beginning body bolus breast cancer coil committee concentration conducted cone confirm confirmed constant course covering currently curves cytotoxic daily days decrease disc dose dosed dosing downward drug evaluate evaluation extracellular fitting five flank flash flush function geometry goal growth hours human hypothesis in vivo indicate injected input insults intensities interfere ketone known leading magnet maintained making maps marine matrix measured mice minutes model models monitored mouse natural nature needed negative normalization normalize normalizing nose oxygenation part perfusion plasma positioned possibly post potential pressure procedures produce product quadrature randomized rare reaching received recovery reduced remained representative respiratory review rise saline scanning science significance slice slices slightly space spike sponge staining statistical submitted suggest surface synthesis synthetic tail temperature therapy thereby third throughout tissue treatment trended triple tumor tumors unchanged upward vascular vehicle vein volume vulnerable welsh went whole wise