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Abstract #1590

Visualization of Drug Dissolution Using 19F-MRS and -MRI

Janet Friedrich1, Julia Schrder1, Sarah Kindgen2, Stefan Fischer1, Mark Schuppert1, Karsten Gogoll2, Peter Langguth2, Laura Maria Schreiber1

1Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Institute of Pharmaceutical Technology and Biopharmacy, Johannes Gutenberg University, Mainz, Germany

Oral applications represent the most important way for administration of active pharmaceutical ingredients. The present work introduces an MRI technique which allows for the investigation of these processes. A 19F solenoid transmit and receive coil was built for in vitro MRI in microcentrifuge-tubes. It provided homogenous RF transmission and reception throughout the whole measurement volume. Perfluoro crown ether emulsion embedded in alginate capsules was imaged. The exponential dissolution process of fluor tablets in water within a 1.5-mL-microcentrifuge-tube was visualized successfully for 15 minutes using 19F-MRS.

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Keywords

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