Meeting Banner
Abstract #1553

The Effect of Iodinated Contrast Media on Glomerular Filtration as Evaluated with Dynamic 3D-MR Renography

Yudong Zhang1, Jing Wang2, Xiaoying Wang3

1Department of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, Jiangsu, China; 2Peking University, Beijing, China; 3Peking University First Hospital, Beijing, China

Glomerular filtration is the main function of the kidney. Currently, we have described a proposed way for determining the single kidney GFR noninvasively by using DCE-MRI. The study has demonstrated that nonionic, high-osmolality iopamidol produces an acute hemodynamic response of kidney function that is associated with a significant deficiency in cortical blood circulation following with a prominent decrease in glomerular clearance rate. These findings suggest that non-invasive MRR method may be of value for the detection and quantification of altered glomerular filtration function as the basis for the evaluation of normal and pathological states such as Contrast-induced nephropathy.

Abstract PDF

Keywords

accordance accordingly acute administration adverse affiliated altered analyzed animal aorta approved arrow black blood body calculation care caused characteristic china circulation clearance clinically committee compartment concentration conducted contrast control coronal corrected correction cortical curve decrease decreased decreases deficiency defined derived descending described despot detection determining diagnosed diagnostics dosage dose dynamic earlier elevated england estimating evaluated evaluation event every exchange extraction filtration findings fitted flattened flow fraction function functional good healthy helpful hospital hour hypothesized illustrates illustration immediate included induced injection injury intravenous invasive iodinated kidney kidneys kinetic known labeled least male maps marker mass materials measures media medical medicine minutes model modeling nonionic nonlinear notoriously oblique observe outer paired pathological peak period poor post prescribed produces prominent protocol quantification quantify rabbit rabbits radiology rapid rather received reduction reflecting relatively remarkable renal representative resolved response reveal scanner serially series several significantly slowed specifically squares successfully suggest tracer tubular understand unfortunately volume white