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Abstract #1552

Simultaneous Measurement of GFR by DCE-MRI and FITC-Sinistrin Clearance in Rats at 3.0 T

Frank G. Zllner1, Daniel Schock-Kusch2, Sandra Bcker2, Sabine Neudecker2, Norbert Gretz2, Lothar R. Schad1

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany; 2Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany

Recent clinical techniques for the estimation of GFR, such as clearance of inulin or sinistrin, scintigraphy with radio-labeled markers, and creatinine clearance are limited. Recent techniques to overcome some of the mentioned limitations are dynamic contrast enhanced magnet resonance imaging (DCE-MRI) or transcutaneous approaches based on fluorescent tracer molecules. The goal was to investigate if a simultaneous measurement was feasible and how MRI-GFR and optical-GFR correlate.Simultaneous measurement of the GFR by two non-invasive techniques namely, DCE-MRI and transcutaneous FITC-sinistrin clearance in rats is feasible. Furthermore, good agreement between the measured GFR values in healthy animals could be achieved.

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