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Abstract #1511

Intra- And Interindividual Differences in Fatty Acid Composition at Various Locations of the Body Assessed By1H-MRS

Jrgen Machann1, Erwin Schleicher2, Christian Wrslin1, Andreas Fritsche2, Fritz Schick1

1Department of Radiology, Section on Experimental Radiology, University Hospital Tbingen, Tbingen, Germany; 2Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tbingen, Tbingen, Germany

In order to determine intra- and interindividual differences in fatty acid composition at different locations of the body, 1H-MRS of adipose tissue was performed in subcutaneous adipose tissue (SCAT) of the neck and the calf, deep and superficial adipose tissue in the abdomen, tibial bone marrow and visceral adipose tissue (VAT) in 20 males. Examinations were performed at 3T applying a STEAM technique. Ratios of mono- and polyunsaturated fatty acids and methyl-protons were calculated. There are significant differences in unsaturation between the locations and between individuals with bone marrow showing the lowest (0.518) and SCATcalf the highest ratio (0.655). VAT seems to play a special role as there is a strong negative correlation between unsaturation and %VAT.

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Keywords

abdomen abdominal accumulation acid acids activity additionally adipose amount anthropometric applying assess assessed automatic axial besides bingen body bone calf characterized chemistry clear clinical compartments composition conditions consequence contamination correlation correlations days deep denoted depending determination determined diseases distribution dominating eluding endocrinology even evidence examinations excellent expansion experimental extreme fast fatty fritz furthermore future gender healthy highest hospital humans inclusions increasing indicate indicated indicates insight insulin inter internal intervention intra invasive involved known lead lean lifestyle limited little locations longitudinal lowest mainly male males mantle marrow material metabolic mono neck needed negative often pathogenesis post predictive prior probable procedure processing promises prospective protective quantification radiology recorded regarding related remains resistance reveals rule scat section seems serving significantly sonata special specimen spectra spectroscopic steam strong studies subcutaneous superficial surrounding thought tissue trio twenty type underwent unsaturated variability variance variation variations various vinyl visceral volumes volunteers water week whereas whether whole years yellow