Meeting Banner
Abstract #1510

Comparison Between Digital Biopsy and MRI Quantification of Hepatic Fat in NAFLD

Samantha Flood1, Eric Meng2, Melanie Beaton3, Lanette J. Friesen-Waldner4, Congyu Zhang5, Charles A. McKenzie1

1Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; 2Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada; 3Department of Medicine, The University of Western Ontario, London, Ontario, Canada; 4Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 5Engineering, The University of Toronto, Toronto, Ontario, Canada

Non-Alcoholic Fatty Liver Disease (NAFLD) is the leading form of liver disease worldwide in both adults and children. Forty-five patients with confirmed NAFLD underwent multiple MRIs and biopsies. Proton Density Fat Fraction was calculated from IDEAL MRI and area fat fraction was calculated from digitised biopsy samples. Results from two raters were compared to determine reproducibility of the MRI and biopsy derived fat fractions. Fat fractions determined by biopsy and MRI correlate strongly and have similarly high inter-rater reproducibility. These results suggest that MRI is a good non-invasive option for quantifying hepatic fat.

Abstract PDF

Keywords

accurate achieve acknowledge acknowledgments adults agreement alcoholic alternative analysts animal approved array audience benefit best biophysics biopsies biopsy board brunt calibrated cessation chairs chemical children clinical clinicians close coil commenced comparable comparing confirmed confounding consent content corrected correlate correlation demonstrating density dentistry derived determine determined diagnosed digital digitally discovery disease distinction engineering entire equivalent essentially ethics excellent excluded five fixed flood form forty foundation fraction fractions give good gratefully great hepatic humans ideal impressive informed initiated inter intercept iron just length likely linear liver lobe location maps matrix measured measures medical medicine missing models monitor months often outlined parallel particularly patient patients physician placed precise prior program proximity quantification quantify quantifying quantitative rater raters received report reproducibility researchers samples school sections separation serum services settings slices slope software spectral spectroscopy stained strong structures suggests support taken target tissue tool torso train treatment triglyceride unguided unknown vacuoles versus vesicles water western worldwide