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Abstract #1451

Semi-Automatic Ventilation Defect Analysis Comparing 1-Liter and 300-Ml 3D Radial and Multi-Slice GRE Imaging Using Hyperpolarized 129Xe in Non-Smoking Older Volunteers

Mu He1, 2, Suryanarayanan S. Kaushik1, 3, Matthew S. Freeman4, Rohan S. Virgincar1, 3, Scott H. Robertson1, John Davies5, Jane Stiles5, William Michael Foster5, H. Page Mcadams6, Bastiaan Driehuys, 34

1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States; 2Department of Electrical and Computer Engineering, Duke University, Durham, NC, United States; 3Department of Biomedical Engineering, Duke University, Durham, NC, United States; 4Center for In Vivo Microscopy, Duke University, Durham, NC, United States; 5Department of Medicine Pulmonary, Duke University Medical Center, Durham, NC, United States; 6Department of Radiology, Duke University Medical Center, Durham, NC, United States

Clinical hyperpolarized 129Xe has shown significant progress recently but scan logistics and cost remain constrained by the need for large volumes of 129Xe. This could be addressed by using lower volumes of 129Xe, but doing so requires understanding the limits this imposes on the ability to quantify the images as well as the value of different acquisition strategies. In this work, we evaluate subtle ventilation defects seen in older healthy volunteers using two dose volumes (1L and 300ml) with both a multi-slice GRE and 3D radial pulse sequence.

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Keywords

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