Meeting Banner
Abstract #1450

Hyperpolarized Xenon-129 3D-Chemical Shift Imaging of the Lung in Subjects with a History of Smoke Exposure

Carolina Fernandes1, Kai Ruppert2, Talissa A. Altes2, John P. Mugler, III2, Iulian C. Ruset3, Wilson Miller2, F. William Hersman3, Jaime F. Mata2

1Institute of Biophysics and Biomedical Engineering, FCUL, Lisbon, Portugal; 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; 3Xemed LLC, Durham, NH, United States

The aim of this work was to assess lung physiology in subjects with different degrees of smoke exposure, and comparing it with the results obtained from healthy subjects. We used a 3D Single Breath-hold CSI technique for generating maps that reflect the amount of xenon-129 gas in the alveoli and dissolved in the lung tissue and red blood cells. The results demonstrated that smoke exposed subjects presented a higher ratio of gas dissolved in the tissue to that dissolved in the red blood cells. This technique proved to be able to provide detailed regional information, with potential to detect small changes in the progression of various pulmonary diseases.

Abstract PDF Poster PDF

Keywords

abstract acquisition airspaces already alveolar application applied approved approximately assessing assessment biomedical biophysics blood breath built capillary cells chemical cigarette clinical coil combination compartments consent coronal corrected correlation cystic decay decaying detected determined diseases dissolved distribution done eight elevated elucidate engineering enrolled entire etiology evaluating exchange exposed exposure expressed fibrosis filtered fraction free frequency function gave generated grant hand healthy heterogeneous history hold house humans impaired implementation induction inflammation informed inhaled insights institute interpolated john likely linear local lung lungs manner maps matrix medical miller package participate perfusion pixel polarization positioned post potential previous processing pulmonary pulse radiology receive reduced refinement regional relatively report resolution slice smoke smoker smokers software solutions strong studies subject subjects supported system table thickening tissue transformed transmit tuned underwent uptake various ventilation wall whether whose xenon zero