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Abstract #1447

Characterization of Dissolved-Phase Xenon-129 Properties in the Human Lung

Kun Qing1, Kai Ruppert2, Yun Jiang3, Jaime F. Mata2, G. Wilson Miller2, Yun Michael Shim4, Chengbo Wang2, Iulian C. Ruset5, 6, F. William Hersman5, 6, Talissa A. Altes2, John P. Mugler, III, 12

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; 3Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 4Medicine, Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, United States; 5Xemed LLC, Durham, NH, United States; 6Physics, University of New Hampshire, Durham, NH, United States

The characteristics of the red blood cell (RBC) and tissue/plasma components of hyperpolarized xenon-129 dissolved in the human lung are not well established. The purpose of this study was to determine, from whole-lung measurements, the fractions and T2* values for the RBC and tissue/plasma components for healthy and diseased subjects, and explore their dependence on degree of lung inflation. In healthy subjects, RBC fraction and T2*, and tissue/plasma T2*, showed little variation among subjects. RBC fraction and tissue/plasma T2* were found to depend on lung inflation. RBC fraction was significantly lower in the diseased subjects than in healthy subjects.

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Keywords

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