Differential Play of Macrophages and T-Lymphocytes in Acute Allograft Cardiac Rejection: in vivo Cellular MRI Detection with a New Iron-Oxide Particle

Keywords

abdomen ability acute administered administration advantageous agent agents aids allows amino animal another axis biological biomedical blue cationic cell cells cellular challenging charge chemical circles class classes close coated configuration conjugating contain containing continues contrast coronary culture despite detected developed developing distribution earlier enlarged exhibit exhibited exhibits feasibility fluorescent generally glycol goes graft heart hearts immune immunity in vivo incorporated incorporation increasing incubation indicates infiltration intensity investigation iron isolated label labeled loading long lung lungs lymphocytes macrophage macrophages makes manipulation manipulations many mechanistic mediated micrometer mode model moderate monitored moreover motion native natural need normalized observation open operation operational organ outcome overcome oxide panels partial particle particles peptides play players polyethylene positive post preliminary preserved pressure probes processes progresses progression recovers rejecting rejection resolution rodent roles sciences severe severity short simple spatial spleens strategies studied sufficient surface taken temporal terminal therapeutic track tracking transplant transplantation transplanted understanding useful valuable various ventricle view volume