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Abstract #1340

Retrospectively Triggered Local PWV Measurements in the Murine Aorta Using a Radial Sampling

Patrick Winter1, Eberhard Rommel1, Wolfgang Rudolf Bauer2, Peter M. Jakob1, 3, Volker Herold1

1Dept. of Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Medizinische Klinik und Poliklinik I, Universittsklinikum Wrzburg, Wrzburg, Germany; 3Magnetic Resonance Bavaria, Wrzburg, Bavaria, Germany

In this work, we introduce a retrospectively triggered PC-FLASH sequence with a radial sampling for a robust measurement of the local pulse-wave-velocity (PWV) in the murine abdominal aorta. The sequence was tested on a 17.6T small animal system on mice. A Navigator signal was extracted from the k-space center and used for the retrospective reconstruction of movie frames of the aortic motion. The PWV was determined using the QA-method. The results were compared with a prospectively triggered radial PWV measurement using a pneumatic measurement of the thoracic motion as trigger signal. The PWV value obtained with the retrospective measurement

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Keywords

abdominal accepted accordance achieve acknowledgments acquisition anesthetized animal aorta aortic approximated arterial asymmetry bandwidth blood calculation cardiovascular carried cause centric cine coil compensated conducted consists contrast correction coverage cross cycle delay dept determined developed diagnosis displayed disturbances divided early eddy enables encoding errors estimation example field fields flash flow frame frames frequency function golden good gradient grants healthy heart important in vivo independent inhomogeneous interferences interleaved last length linear local makes materials mice minimize minutes model modified modulated modulation monitoring motion mouse movie navigation navigator peter peters physics pneumatic position previous probes problems projection projections prospectively pulse quality quantify radial readout recent reconstructed reconstruction reduce reduced resolution respiratory retrospective retrospectively risks river sampling section sectional segment segmentation segments short slice slope space spatial starting step steps stiffness strongly studies supported suppressed system systolic taken temporal thoracic tool trajectory trans trigger triggered triggering uniform velocity vessel visible volume wave whole width window winter wireless