Meeting Banner
Abstract #1317

A Multimodality Cross-Validation Study of Cardiac Perfusion Using MR and CT

Giorgos Papanastasiou1, 2, Lucy Kershaw1, Michelle Williams2, Mark Dweck2, Shirjel Alam2, Saeed Mirsadraee1, Calum Gray1, Tom MacGillivray1, David C. Newby1, 2, Scott I. Semple1, 2

1Clinical Research Imaging Center, University of Edinburgh, Edinburgh, United Kingdom; 2Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom

Modern advances in magnetic resonance (MR) and computed tomography (CT) perfusion imaging techniques have developed methods for myocardial perfusion assessment. However, individual imaging techniques present limitations that are possible to be surpassed by a multimodality cross-validation of perfusion imaging and analysis. We calculated the absolute myocardial blood flow (MBF) in MR using a Fermi function and the transmural perfusion ratio (TPR) in CT perfusion data in a patient with coronary artery disease (CAD). Comparison of MBF and TPR results showed good correlation emphasizing a promising potential to continue our multimodality perfusion assessment in a cohort of patients with CAD.

Keywords

abnormal absolute according accurate acquisition adapting agent aims albeit although anterior apex apical applied appropriate artery assessed assessment assessments automatically axis benefit better blinded blue body bullseye cardiac cardiologist cardiovascular challenging clinical clinically computed concentration conditions consented considered contour contoured contrast coronary correlation cross currently datasets decrease decreased decreases defect detection diastole direct directly disease doses dynamic equation established establishing excluded function gain gated generated generation good gray healthy heart identified improved index indirect infusion inversion iodine journal kingdom lesions limitations locker look male mass measured measuring medical medicine mild model modeling moderate motion myocardial myocardium observers panel pass patients perfusion placed population previously protocol quality quantification quantify radiation readily receiving recovery reduced relationship relatively reported requires resolution respectively rest robust scanner science segment segmentation segments short significantly since slice snapshot software spatial still stress subject subset susceptibility systems tissue tomography unit upper validated validation valuable ventricle versus vital volume volunteers