Meeting Banner
Abstract #1301

3D Inversion Recovery Fast Spoiled Gradient Recall (IR-FSPGR) and TOF MRA with Morphology Enhanced Probabilistic Plaque Segmentation (MEPPS) Predicts the Size of Lipid-Rich Necrotic Core of Carotid Plaque

J. Kevin DeMarco1, Hideki Ota2, David Zhu1, William Kerwin3, Chun Yuan3

1Michigan State University, East Lansing, MI, United States; 2Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan; 3University of Washington, Seattle, WA, United States

The purpose of this study was to test the feasibility of automated segmentation of two non-contrast MR sequences to predict the size of necrotic-core identified by manual segmentation of multi-contrast carotid plaque MRI. Forty-eight arteries from 26 consecutive patients were analyzed. Automated segmentation identified all 16 carotid plaques harboring moderate/large necrotic-core with 6 additional false positive studies and excluded 54% of the carotid arteries as not having significant necrotic core. The addition of 3D IR-FSPGR to clinical MRA evaluation of carotid stenosis could help identify patients potentially harboring moderate/large necrotic-core who might be candidates for new aggressive lipid-lowering therapies.

Abstract PDF Poster PDF

Keywords

accordingly addition additional aggressive arteries artery asymptomatic audience automated automatic axial benefit bifurcation bifurcations bilateral calcification carotid channel characteristics clinical clinicians coil confirmed consensus contain contrast convention core criteria dedicated demonstrating develop diagnostic disease duplex enhanced evaluate excellent excluded experienced false fast features fibrous field final flight future gold good gradient guide harboring histology identified identify include included includes individual initial interpreted inversion japan larger lead least lipid lumen manual manually materials matrix measured medical medium might moderate morphology necrotic negative noted occluded outer outlining paired patients peer performance phenotype plaque plaques poor positive potentially predictive predicts previously prior probabilistic process proposed protocol quality radiologists radiology rapid rapidly recovery remaining removed reported review reviewed reviewers rich risk rupture score screen screening segmentation segmented sensitivity slice smaller software specificity spoiled stroke studies subgroup subjects suggest suitable surgeons target therapy third treating treatment true twenty underwent utilizing validated vascular volume wall weightings yuan