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Abstract #1181

Probing Distraction to Cognitive Control Using Real-Time fMRI

Jeremy F. Magland1, Anna Rose Childress2

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Real-time functional MRI (rtfMRI) feedback can potentially provide therapeutic cognitive training for various disorders. In the case of addiction therapy, the feedback paradigm design is especially challenging because asking patients to alternate between craving and non-craving states is not ideal. Here we introduce a new indirect rtfMRI feedback paradigm for probing cognitive control in real time and measuring disruption in the face of various distractions cues. Preliminary results suggest that distraction effects can be detected in real time for both patients and controls, and that participants may be able to use neurofeedback to learn to stay focused despite distraction.

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Keywords

able abuse accurate activity addiction among applications attempts aversive biological bold brain categories challenging characterize charms choices chronic classification classifier cocaine cognitive comprising content context continue continuous control controls course craving cues decrease deep depicted design despite developing diagram dips direct display disruption distracted distraction distractions drug efficacy evidence evident exposure face fatigue feedback focused focusing fourth frequent function functional furthermore gain healthy help hidden hour human hypothesis illustrate imagine indirect individuals instructed instructions intervals involves known lasted learn learned learning least limbic lobe mapping measure modulation movement navigating noise notable overall overcome pain paradigm paradigms particularly patients performance periphery picture pictures preliminary processed protocol psychiatry pulse radiology real reasons repetitions rest restricted retrospective scanned scanner scene score seeking separated session sham slices software spinner stay structures studies subjects suggesting target task therapeutic therapy throughout tracked treatment type types typical unclear variety various visible visual voluntary whereas whether whole window worse