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Abstract #1180

Altered Interoception and Resting-State Functional Connectivity in the Insular System of Cocaine Dependents

Yuzheng Hu1, Hong Gu1, Betty Jo Salmeron1, Lia Liang1, Elliot Stein1, Yihong Yang1

1Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States

Accumulative evidence has indicated the involvement of the insular system in drug addiction by its fundamental role in interoception. However, relationship between the interoception, neurobiological measures of insula and addiction behaviors remains unclear. To address this question, the current study employed Toronto Alethymia Scale and resting-state functional connectivity (FC) method to cocaine dependents and well-matched controls. Elevated TAS score and decreased FC of insula-ACC circuitry as well as their disrupted relationship were found in cocaine group, suggesting disturbance of the interoceptive function and underlying neurobiological bases in drug addiction.

Keywords

abnormal abuse accumulative acknowledgment activity addicted addiction addictive addition addressing adopted aimed alcoholics alterations altered anterior assess behavior behaviors bilateral brain branch characterized chronic cocaine cognitive collected compulsive confounding connectivity consequences consistent controls corrections correlated correlation craving criteria damage decreased deficit dependence dependents despite disorder disrupt disturbance drug education elevated emotion especially evidence examine examined example externally filtering findings forty function functional fundamental gender head health healthy hemisphere highlight hong imply important indicated indicates individuals induced institute institutes insular intramural intrinsic involvement journal linking matched meanwhile measure measures mixed models money motion national negative normalization oriented participant participated paucity perception plays poor positive positively potential previous processed program proposed reflect regression relapsing relate relationship relationships remarkable removing reported resting revealed role scale science score seeds seeking seven significantly slice smoking smoothing spent stein steps strengths structure studies subjects substance suggested suggesting supported system task thinking timing trends underlying upon view yang