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Abstract #1166

Altered Functional Connectivity Consistent with Associated Language Impairment in Rolandic Epilepsy

Ren M.H. Besseling1, Jacobus Jansen2, Geke Overvliet3, Sylvie J. van der Kruijs4, Johannes Vles3, Saskia Ebus4, Paul A.M. Hofman2, Anton de Louw4, Albert P. Aldenkamp4, Walter H. Backes2

1Radiology, Maastricht University, Maastricht, Limburg, Netherlands; 2Radiology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands; 3Neurology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands; 4Epilepsy Centre Kempenhaeghe, Heeze, Noord-Brabant, Netherlands

Rolandic epilepsy (RE) has been associated with language impairment, the cerebral mechanism of which is unknown. Independent component analysis of resting-state fMRI data was used to identify the functional network involving the pre- and postcentral gyri, i.e. the rolandic cortex (from which the seizures originate). Compared to controls, this network showed reduced connectivity with the left inferior frontal gyrus in a region of interest defined from word-generation task fMRI (p=0.011). This represents an abnormality in a functional network involving the rolandic cortex which provides a substrate for language impairment in RE.

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Keywords

aberrant abnormalities according acquisition activation activity affect allele allocate altered among anti audience awareness behavior benign bilateral block blue boys brain carriers childhood children classically clinical cognitive coincided complicated component concatenated connectivity considered consistent context controls coordinate core corrected correlations cortex criteria defined disorder disorders distinct drugs epilepsy epileptic epsilon equal evolution expressive extended facilitate findings frontal functional functionality fundamentals future general generation green healthy identify impairment impairments independent individual inferior informed inset integrative intervals intrinsic investigations involved involving language link local mapped matched medical might mild natl network networks neurology organization originating others particular patients patterns performance permutation potential predictive prevented probabilistic question radiology radius raised reading recent reduced reduction regression relatively remains remission represent resolve resolved respect resting score seizure seizures selected sided speech spikes studies subject suggested superior system target task tasks temporal therapy topologically trans transient treat trends twenty underwent unknown whether white wise word years young