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Abstract #1158

The Altered Value-Based Intrinsic Network and Its Association with Impulsive Behavior in Abstinent Heroin Dependent Subjects

Tianye Zhai1, 2, Tianye Zhai3, Chunming Xie1, 2, Zheng Yang1, Shi-Jiang Li2

1Center of Brain and Cognition, Beijing Institute of Basic Medical Science, Beijing, China; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Neurobiological and neuroimaging studies have demonstrated that the ventral medial prefrontal cortex (vmPFC), a major node for decision making, is crucial in drug addiction. 1,2 However, little is known about the role of the vmPFC network and its relation to drug-seeking behaviors, such as impulsivity in addiction. In this study, we utilized resting-state functional connectivity fMRI (R-fMRI) to investigate the alteration of the vmPFC network and its relationship to impulsivity in abstinent heroin dependent subjects (HD) and control nondrug users (CN).

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Keywords

abstinent academy accordance addiction altered analyzed anatomical approved association atrophy basic behavior behaviors beta bilateral biomedical biophysics blue brain bright china closed cluster coefficient cognition college color committee conducted connectivity control correct corrected correction correlates correlating correlation cortex course covariance cross crucial datasets declaration decreased delta dependent detect distinct dorsal drug dysfunction ethics exposure extends eyes filter finding fluctuation frequency frontal functional generated global grant grants gray hand head heroin identify impulse impulsive index indicates individual inferior informed institute instructed investigate keep known lateral linear literature little located long major making maps matched matrix measured medial medical ministry motion negative network neural neuron node normalized nucleus patterns physiological positive posterior preprocessing prior program quantified registration regression relation removal resolution resting role sample scale science sciences scores seed seeking served sets shot sides significantly slice software space stable statistical studies subject subjects supported twenty underpinnings understanding union users ventral volume white whole