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Abstract #1157

Effect of Injury Severity on Brain Activations and Functional Connectivity Density Mapping in Survivors of Traumatic Brain Injury

Abigail Livny-Ezer1, 2, Mark Weiser3, 4, Tammar Kushnir2, 4, Sagi Harnof5, Dardo Tomasi6, 7, Chen Hoffman2, Anat Biegon8, 9

1J. Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; 2Diagnostic Imaging Dept., Sheba Medical Center, Tel Hashomer, Israel; 3Dept. of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel; 4Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 5Dept. of Neurosurgery, Sheba Medical Center, Tel Hashomer, Israel; 6National Institutes of Health, Bethesda, MD, United States; 7Medical Dept. , Brookhaven National Laboratory, Upton, NY, United States; 8Medical Dept., Brookhaven National Laboratory, Upton, NY, United States; 9Dept. of Neurology, Stony Brook University, Stony Brook, NY, United States

Survivors of Traumatic brain injury (TBI) suffer from cognitive deficits. The aim of this study was to assess the influence of injury severity on patterns of brain activation during a working memory task with fMRI. Twelve mild, 10 moderate-severe patients and 19 controls performed an N-back task for letters. Activations in the low memory load did not appear to be related to injury severity. High memory load activated additional areas in the TBI groups compared to controls and was dependent on injury severity. In addition, TBI patients presented a different pattern of functional connectivity mapping in resting-state compared to controls.

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Keywords

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