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Abstract #1090

Grey Matter Perfusion Abnormalities Are More Extensive Than Grey Matter Atrophy in Early Relapsing-Remitting Multiple Sclerosis Patients

Laetitia Debernard1, Tracy R. Melzer1, Saskia Van Stockum1, Jane Eagle1, Charlotte Graham1, Daniel Myall1, Claudia Angela M. Wheeler-Kingshott2, John C. Dalrymple-Alford1, David H. Miller1, 2, Deborah F. Mason1

1New Zealand Brain Research Institute, Christchurch, Canterbury, New Zealand; 2NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom

Magnetic Resonance Imaging (MRI) is the clinical gold standard to diagnose Multiple Sclerosis (MS). Robust early prognostic markers are needed to accurately follow MS disease. The objective of this study is 1) to investigate grey matter (GM) atrophy and perfusion abnormalities in early relapsing-remitting MS patients, and 2) to correlate these findings with clinical and cognitive impairments. The coupling of both imaging modalities in the same patient sample will enable a more complete description of early pathological mechanisms in MS disease.

Keywords

abnormalities absence acquisition addition aimed arterial assess assessed assessments assists atrophy audience blood brain cerebral channel chard clinical cognitive coil complete composite confirmed consistent controls corrected correlate cortex cortical covariates decrease decreased deep delay demographic description descriptive detect detecting deviation diagnosis disability discovery disease duration dysfunction eagle early education either electric evidence evident evolution expanded experimental extensive false female findings flair flow frontal functional future gender general generated global good head healthy identified impairments in vivo institute intact investigate investigated john labeling lesion lesions limited load loads longitudinal loss manually mason matrix measure metabolic metabolism miller modalities neurological neuronal often outcome outlined parietal patient patients performance perfusion post predict preprocessing program proof propeller queen question rather reduced reductions reflect regional relapsing relatively remitting required sample scale sclerosis score scores segmentation serial severity smoothing software square status structural studies summarized symptom system table target thalamus therapies toolbox underwent unit volume wheeler whether white years